Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

Malika El Yacoubi; Catherine Ledent; Marc Parmentier; Jean Costentin; Jean-Marie Vaugeois

Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

Malika El Yacoubi ¹ Catherine Ledent ² Marc Parmentier ² Jean Costentin ¹ Jean-Marie Vaugeois ¹

1 Neuropsycho-pharmacologie expérimentale

2 ULB - Université Libre de Bruxelles [Bruxelles]

Abstract : Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.

Keywords : (Mouse) Caffeine Adenosine A2A receptor

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

Liste complète des métadonnées

https://hal-normandie-univ.archives-ouvertes.fr/hal-02185492
Contributeur : Université Normandie <>
Soumis le : mardi 16 juillet 2019 - 16:22:05
Dernière modification le : vendredi 19 juillet 2019 - 10:24:06

Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

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Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

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