Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

Malika El Yacoubi (1) , Catherine Ledent (2) , Marc Parmentier (2) , Jean Costentin (1) , Jean-Marie Vaugeois (1)

1 Neuropsycho-pharmacologie expérimentale
2 ULB - Université libre de Bruxelles

Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.

Keywords: (Mouse); Adenosine A2A receptor; Caffeine

Domains: Life Sciences [q-bio]; Human health and pathology

Malika El Yacoubi, Catherine Ledent, Marc Parmentier, Jean Costentin, Jean-Marie Vaugeois. Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice. European Journal of Pharmacology, 2005, 519 (3), pp.290-1. ⟨10.1016/j.ejphar.2005.07.022⟩. ⟨hal-02185492⟩