Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

Malika El Yacoubi 1 Catherine Ledent 2 Marc Parmentier 2 Jean Costentin 1 Jean-Marie Vaugeois 1
1 Neuropsycho-pharmacologie expérimentale
2 ULB - Université Libre de Bruxelles [Bruxelles]
Abstract : Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.
Keywords : (Mouse) Caffeine Adenosine A2A receptor
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02185492
Contributeur : Université Normandie <>
Soumis le : mardi 16 juillet 2019 - 16:22:05
Dernière modification le : vendredi 7 février 2020 - 16:30:08

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COMUE-NORMANDIE | CNRS | UNIROUEN

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Malika El Yacoubi, Catherine Ledent, Marc Parmentier, Jean Costentin, Jean-Marie Vaugeois. Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice. European Journal of Pharmacology, 2005, 519 (3), pp.290-1. ⟨10.1016/j.ejphar.2005.07.022⟩. ⟨hal-02185492⟩

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