Skip to Main content Skip to Navigation
Journal articles

Adenosine A2A receptor deficient mice are partially resistant to limbic seizures

Abstract : The neuromodulator adenosine, acting through activation of four defined metabotropic receptors called A(1), A(2A), A(2B) and A(3,) has been proposed as an endogenous anticonvulsant. Here, the consequences of deleting the adenosine A(2A) receptor have been examined in different experimental models of epilepsy. A(2A)R KO mice were not protected against seizures originating from brainstem structures, namely electroshock-induced seizures. The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals. A(2A)R KO mice exhibited reduced pentylenetetrazol-induced kindled seizures, demonstrating an important role of the A(2A) receptor in the acquisition of kindling. These data suggest that adenosine stimulating A(2A) receptors modulates excitatory neurotransmission and exacerbates limbic seizures. It is therefore suggested that adenosine A(2A) receptor antagonists might offer protection from some epileptic syndromes.
Document type :
Journal articles
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-02185491
Contributor : Université Normandie <>
Submitted on : Tuesday, July 16, 2019 - 4:22:02 PM
Last modification on : Thursday, June 4, 2020 - 10:24:09 AM

Links full text

Identifiers

Citation

Malika El Yacoubi, Catherine Ledent, Marc Parmentier, Jean Costentin, Jean-Marie Vaugeois. Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. Naunyn-Schmiedeberg's Archives of Pharmacology, 2009, 380 (3), pp.223-32. ⟨10.1007/s00210-009-0426-8⟩. ⟨hal-02185491⟩

Share

Metrics

Record views

57