Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Adenosine A2A receptor deficient mice are partially resistant to limbic seizures

Abstract : The neuromodulator adenosine, acting through activation of four defined metabotropic receptors called A(1), A(2A), A(2B) and A(3,) has been proposed as an endogenous anticonvulsant. Here, the consequences of deleting the adenosine A(2A) receptor have been examined in different experimental models of epilepsy. A(2A)R KO mice were not protected against seizures originating from brainstem structures, namely electroshock-induced seizures. The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals. A(2A)R KO mice exhibited reduced pentylenetetrazol-induced kindled seizures, demonstrating an important role of the A(2A) receptor in the acquisition of kindling. These data suggest that adenosine stimulating A(2A) receptors modulates excitatory neurotransmission and exacerbates limbic seizures. It is therefore suggested that adenosine A(2A) receptor antagonists might offer protection from some epileptic syndromes.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Université Normandie <>
Soumis le : mardi 16 juillet 2019 - 16:22:02
Dernière modification le : jeudi 4 juin 2020 - 10:24:09

Lien texte intégral



Malika El Yacoubi, Catherine Ledent, Marc Parmentier, Jean Costentin, Jean-Marie Vaugeois. Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. Naunyn-Schmiedeberg's Archives of Pharmacology, 2009, 380 (3), pp.223-32. ⟨10.1007/s00210-009-0426-8⟩. ⟨hal-02185491⟩



Consultations de la notice