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Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine

Abstract : Long-term caffeine intake has been reported to decrease the susceptibility to convulsants in mice. Occurrence of seizures following long-term oral administration of caffeine (0.3g/l) was investigated using adenosine A(2A) receptor knockout (A(2A)R KO) and control (A(2A)R WT) mice. Clonic seizures induced by acute pentylenetetrazol (PTZ, 50mg/kg i.p.) were significantly attenuated in adenosine A(2A)R KO mice drinking only water and reduced by a 14-day caffeine treatment in adenosine A(2A)R WT mice. In addition we showed a protecting effect of a 21-day caffeine treatment in A(2A)R WT mice against kindled seizures induced by PTZ in an increasing dose schedule. Summing up, these protective effects against PTZ-induced seizures occurring when adenosine A(2A)R is absent or chronically blocked by a relevant dose of caffeine may be related to a decreased neuronal excitability.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02185485
Contributor : Université Normandie <>
Submitted on : Tuesday, July 16, 2019 - 4:21:49 PM
Last modification on : Friday, August 21, 2020 - 10:50:08 AM

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Malika El Yacoubi, Catherine Ledent, Marc Parmentier, Jean Costentin, Jean-Marie Vaugeois. Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. Neuropharmacology, Elsevier, 2008, 55 (1), pp.35-40. ⟨10.1016/j.neuropharm.2008.04.007⟩. ⟨hal-02185485⟩

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