Actions of adenosine at its receptors in the CNS insights from knockouts and drugs

Bertil B Fredholm 1 Jiang-Fan Chen 2 Susan A Masino 3 Jean-Marie Vaugeois 4
1 Karolinska Institutet [Stockholm]
2 UC - University of Coimbra [Portugal]
3 Trinity College Hartford
4 Neuropsycho-pharmacologie expérimentale
Abstract : Adenosine and its receptors have been the topic of many recent reviews. These reviews provide a good summary of much of the relevant literature--including the older literature. We have, therefore, chosen to focus the present review on the insights gained from recent studies on genetically modified mice, particularly with respect to the function of adenosine receptors and their potential as therapeutic targets. The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted.
Keywords : A2A receptor A1 receptor affeine Ischemia Parkinson's disease Pain
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Article dans une revue
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02185481
Contributeur : Université Normandie <>
Soumis le : mardi 16 juillet 2019 - 16:21:37
Dernière modification le : vendredi 19 juillet 2019 - 10:24:06

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  • HAL Id : hal-02185481, version 1
  • PUBMED : 15822182

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COMUE-NORMANDIE | CNRS | UNIROUEN

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Bertil B Fredholm, Jiang-Fan Chen, Susan A Masino, Jean-Marie Vaugeois. Actions of adenosine at its receptors in the CNS insights from knockouts and drugs. Annual Review of Pharmacology and Toxicology, Annual Reviews, 2005, 45, pp.385-412. ⟨hal-02185481⟩

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