Alterations in 5-HT1B receptor function by p11 in depression-like states - Normandie Université Accéder directement au contenu
Article Dans Une Revue Science Année : 2006

Alterations in 5-HT1B receptor function by p11 in depression-like states

Résumé

The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Fichier non déposé

Dates et versions

hal-02185479 , version 1 (16-07-2019)

Identifiants

Citer

Per Svenningsson, Karima Chergui, Ilan Rachleff, Marc Flajolet, Xiaoqun Zhang, et al.. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science, 2006, 311 (5757), pp.77-80. ⟨10.1126/science.1117571⟩. ⟨hal-02185479⟩
35 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More