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Alterations in 5-HT1B receptor function by p11 in depression-like states

Abstract : The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
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Soumis le : mardi 16 juillet 2019 - 16:21:30
Dernière modification le : vendredi 7 février 2020 - 16:30:08

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Per Svenningsson, Karima Chergui, Ilan Rachleff, Marc Flajolet, Xiaoqun Zhang, et al.. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science, American Association for the Advancement of Science, 2006, 311 (5757), pp.77-80. ⟨10.1126/science.1117571⟩. ⟨hal-02185479⟩



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