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The Enterococcus faecalis superoxide dismutase is essential for its tolerance to vancomycin and penicillin

Abstract : Enterococcus faecalis is a human commensal that has the ability to become a pathogen. Because of its ruggedness, it can persist in the hospital setting and cause serious nosocomial infections. E. faecalis can acquire multiple drug resistance determinants but is also intrinsically tolerant to a number of antibiotics, such as penicillin or vancomycin, meaning that these usually bactericidal drugs only exhibit a bacteriostatic effect. Recently, evidence has been presented that exposure to bactericidal antibiotics induced the production of reactive oxygen species in bacteria. Here, we studied the role of enzymes involved in the oxidative stress response in the survival of E. faecalis after antibiotic treatment.
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Submitted on : Thursday, July 11, 2019 - 5:36:45 PM
Last modification on : Tuesday, March 17, 2020 - 2:59:31 AM

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Alain Bizzini, Chen Zhao, Yanick Auffray, Axel Hartke. The Enterococcus faecalis superoxide dismutase is essential for its tolerance to vancomycin and penicillin. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2009, 64 (6), pp.1196-1202. ⟨10.1093/jac/dkp369⟩. ⟨hal-02180970⟩

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