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Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci

Abstract : Oligocomponent pilus structures, recently discovered in many important Gram-positive pathogens, represent a new class of virulence factors with adhesive and matrix protein-binding activity. Some of these proteins have emerged as very promising lead components of protein-based vaccines against Streptococci. These extended surface structures play key roles in host cell and tissue adherence, paracellular translocation, and biofilm formation of major Gram-positive pathogens such as Streptococcus pyogenes, S. agalactiae, S. pneumoniae as well as in opportunistic and nosocomial pathogens like Enterococci. Here, we discuss the similarities and differences of: (1) the genomic organization of the various regions encoding pilus proteins, (2) the number, type, and assembly of the proteins constituting the pili, (3) their expression and regulation mechanisms, (4) their role in bacterial virulence, and (5) their potential as vaccine candidate antigens.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02180944
Contributor : Axel Hartke <>
Submitted on : Thursday, July 11, 2019 - 5:22:48 PM
Last modification on : Wednesday, June 10, 2020 - 12:36:38 PM

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Bernd Kreikemeyer, Gustavo Gámez, Immaculada Margarit, Jean-Christophe Giard, Sven Hammerschmidt, et al.. Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci. International Journal of Medical Microbiology, Elsevier, 2011, 301 (3), pp.240-251. ⟨10.1016/j.ijmm.2010.09.003⟩. ⟨hal-02180944⟩

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