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Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery

Abstract : We have developed advanced folate bonded to boron nitride (BN) nanocarriers with a high potential for targeted drug delivery. The folic acid (FA) molecules were successfully conjugated to BN nanoparticles (BNNPs) in three consecutive stages (i) FA preactivation by N,N'-dicyclohexylcarbodiimide (DCC), (ii) BNNP modification by AgNPs and their further NH2-functionalization with L-cysteine, and (iii) final conjugation of activated FA to modified BNNPs. To shed light on the FA-BNNPs binding mechanism, detailed energetic analysis of the atomic structure and stability of the FA-BNNPs system using density functional theory (DFT) calculations was carried out. The results indicated that the FA was successfully bonded with the BNNPs by a condensation reaction between amino groups of Cyst-Ag/BNNPs and carboxyl groups of FA using DCC. Theoretical analysis also demonstrated that the grafting of FA to the surface of BNNP does not affect FA targeting properties.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02175443
Contributor : Elisabeth van T Hof <>
Submitted on : Friday, July 5, 2019 - 5:02:21 PM
Last modification on : Tuesday, July 14, 2020 - 11:04:08 AM

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Elizaveta S. Permyakova, Irina V. Sukhorukova, Liubov Yu. Antipina, Anton S. Konopatsky, Andrey M. Kovalskii, et al.. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery. Journal of Physical Chemistry C, American Chemical Society, 2017, 121 (50), pp.28096-28105. ⟨10.1021/acs.jpcc.7b10841⟩. ⟨hal-02175443⟩

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