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Les effets anti-H1 intéressants dans les insomnies de maintien : réflexion sur les intérêts comparés de la doxylamine et de la doxépine

Abstract : Doxylamine (Donormyl®, Lidene®, Generics) is commonly proposed by pharmacists as a sleeping pill which does not require a prescription. In France, today it is only prescribed for occasional insomnia in adults. In light of knowledge about the role of the histamine H1 inverse agonist drugs in the treatment of insomnia, and specifically the low dose doxepin (3 mg and 6 mg) marketed in the US and Canada (Silenor®), we suggest that the use of doxylamine may be appropriate for treating insomnia in the last third of the night. Better information to the pharmacist on the prescription of this anti-H1 hypnotic would be beneficial to the patient.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02173189
Contributor : Jean-Marie Vaugeois <>
Submitted on : Thursday, July 4, 2019 - 12:34:10 PM
Last modification on : Monday, June 29, 2020 - 3:14:03 PM

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G. Dupuis, Jean-Marie Vaugeois. Les effets anti-H1 intéressants dans les insomnies de maintien : réflexion sur les intérêts comparés de la doxylamine et de la doxépine. L'Encéphale, Elsevier Masson, 2019, pp.80-82. ⟨10.1016/j.encep.2019.01.006⟩. ⟨hal-02173189⟩

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