Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Viromes of one year old infants reveal the impact of birth mode on microbiome diversity

Abstract : Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssphage is acquired early in life, both in this cohort and two others, although no difference in birth mode is detected. A previous study has shown that bacterial OTU's (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [18 références]  Voir  Masquer  Télécharger
Contributeur : Marion Dalmasso <>
Soumis le : lundi 24 juin 2019 - 16:18:25
Dernière modification le : mardi 30 juin 2020 - 09:16:58


Fichiers éditeurs autorisés sur une archive ouverte




Angela Mccann, Feargal Ryan, Stephen Stockdale, Marion Dalmasso, Tony Blake, et al.. Viromes of one year old infants reveal the impact of birth mode on microbiome diversity. PeerJ, PeerJ, 2018, 6, pp.e4694. ⟨10.7717/peerj.4694⟩. ⟨hal-02163867⟩



Consultations de la notice


Téléchargements de fichiers