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Cytotoxicity of cationic NHC copper(I) complexes coordinated to 2,2'-bis-pyridyl ligands

Abstract : Cytotoxicity of cationic (NHC)Cu(I) complexes bearing 2,2′-dipyridylamine (dpa) type ligands has been evaluated toward 4 cancer cell lines, and compared to the one of neutral (NHC)Cu(I) complexes. The high cytotoxicity of these novel cationic (NHC)Cu(I) complexes, combined with the straightforward synthesis, and versatility of dpa type ligands may offer new prospects in cancer research, toward the development of novel carrier linked prodrugs.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02159919
Contributor : Jean-Luc Renaud <>
Submitted on : Wednesday, June 19, 2019 - 10:31:47 AM
Last modification on : Thursday, July 2, 2020 - 3:21:39 AM

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Margaux Elie, Gilbert Umuhire Mahoro, Eric Duverger, Jean-Luc Renaud, Richard Daniellou, et al.. Cytotoxicity of cationic NHC copper(I) complexes coordinated to 2,2'-bis-pyridyl ligands. Journal of Organometallic Chemistry, Elsevier, 2019, 893, pp.21-31. ⟨10.1016/j.jorganchem.2019.04.003⟩. ⟨hal-02159919⟩

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