Iron-Catalyzed Tandem Three-Component Alkylation: Access to α-Methylated Substituted Ketones

Léo Bettoni 1 Charlotte Seck 1 Mbaye Diagne Seck 1 Sylvain Gaillard 1 Jean-Luc Renaud 1
1 LCMT - Laboratoire de chimie moléculaire et thioorganique
Abstract : The borrowing hydrogen strategy has been applied in the synthesis of α-branched methylated ketones via a tandem three-component reaction catalyzed by a diaminocyclopentadienone iron tricarbonyl complex. Various alkyl and aromatic methyl ketones underwent dialkylation with various primary alcohols and methanol as alkylating agents in mild reaction conditions and good yields. Deuterium labeling experiments suggested that the benzylic alcohol was the hydrogen source in this tandem process.
Type de document :
Article dans une revue
Liste complète des métadonnées
https://hal-normandie-univ.archives-ouvertes.fr/hal-02159906
Contributeur : Jean-Luc Renaud <>
Soumis le : mercredi 19 juin 2019 - 10:19:06
Dernière modification le : mardi 8 octobre 2019 - 13:52:02

Lien texte intégral

openaccess

Identifiants

Collections

COMUE-NORMANDIE | CNRS | ENSICAEN | LCMT | UNICAEN

Citation

Léo Bettoni, Charlotte Seck, Mbaye Diagne Seck, Sylvain Gaillard, Jean-Luc Renaud. Iron-Catalyzed Tandem Three-Component Alkylation: Access to α-Methylated Substituted Ketones. Organic Letters, American Chemical Society, 2019, 21 (9), pp.3057-3061. ⟨10.1021/acs.orglett.9b00630⟩. ⟨hal-02159906⟩

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

24