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Iron-Catalyzed Tandem Three-Component Alkylation: Access to α-Methylated Substituted Ketones

Abstract : The borrowing hydrogen strategy has been applied in the synthesis of α-branched methylated ketones via a tandem three-component reaction catalyzed by a diaminocyclopentadienone iron tricarbonyl complex. Various alkyl and aromatic methyl ketones underwent dialkylation with various primary alcohols and methanol as alkylating agents in mild reaction conditions and good yields. Deuterium labeling experiments suggested that the benzylic alcohol was the hydrogen source in this tandem process.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02159906
Contributor : Jean-Luc Renaud <>
Submitted on : Wednesday, June 19, 2019 - 10:19:06 AM
Last modification on : Thursday, July 2, 2020 - 3:21:28 AM

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Léo Bettoni, Charlotte Seck, Mbaye Diagne Seck, Sylvain Gaillard, Jean-Luc Renaud. Iron-Catalyzed Tandem Three-Component Alkylation: Access to α-Methylated Substituted Ketones. Organic Letters, American Chemical Society, 2019, 21 (9), pp.3057-3061. ⟨10.1021/acs.orglett.9b00630⟩. ⟨hal-02159906⟩

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