In-Host Adaptation of Salmonella enterica Serotype Dublin during Prosthetic Hip Joint Infection

Faten El Sayed (1, 2) , Guillaume Sapriel (2, 3) , Nizar Fawal (4) , Aurelia Gruber (1) , Thomas Bauer (1) , Beate Heym (1, 2) , Caroline Dupont (1) , Henri-Jean Garchon (2) , Jean-Louis Gaillard (2, 1) , Martin Rottman (1, 5) , Simon Le Hello (4)

1 Hôpital Ambroise Paré [AP-HP]
2 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
3 ABI - Atelier de BioInformatique
4 CNR-ESS - Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella
5 Hôpital Raymond Poincaré [AP-HP]

Genome degradation has been central to the adaptation of Salmonella enterica serotypes to their hosts throughout evolution. We witnessed the patho-adaptation of a strain of Salmonella Dublin (a cattle-adapted serotype) to a human host during the course of a recurrent prosthetic hip joint infection evolving over several years.

Mots clés: France; Salmonella enterica serotype Dublin; adaptation; bacteria; bone and joint infection; epidemiology

Domaines: Virologie; Bactériologie; Microbiologie et Parasitologie

Faten El Sayed, Guillaume Sapriel, Nizar Fawal, Aurelia Gruber, Thomas Bauer, et al.. In-Host Adaptation of Salmonella enterica Serotype Dublin during Prosthetic Hip Joint Infection. Emerging Infectious Diseases, 2018, 24 (12), pp.2360-2363. ⟨10.3201/eid2412.180214⟩. ⟨hal-02155387⟩