Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme.

Hélène Bouraïma Lelong; Barabara Lireux; Hervé Mittre; Annie Benhaim; Michel Herrou; Jacques Mahoudeau; F Guillon-Metz; Marie-Laure Kottler; Yves Reznik

Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme.

Hélène Bouraïma Lelong ¹ Barabara Lireux Hervé Mittre ¹ Annie Benhaim ¹ Michel Herrou Jacques Mahoudeau F Guillon-Metz Marie-Laure Kottler ¹ Yves Reznik ¹

1 OeReCa - Œstrogènes, reproduction, cancer

Abstract : A 30-year-old male was referred for the rapid development of gynecomastia, and dramatic hyperestrogenemia was assessed: plasma estrone, estradiol but also cortisol were not suppressed by high-dose dexamethasone, while gonadotropin pulsatility was completely abolished. A 60-mm right adrenal tumor was evidenced on computed tomography-scan, and the patient underwent adrenalectomy. The tumor was found to express a moderate increase in aromatase activity compared with adjacent non-neoplastic adrenal tissue. Quantitative RT-PCR also showed a weak and non-significant increase in total aromatase mRNA in the tumor compared with normal adrenal tissue. Aromatase transcripts were mainly promoter PII-derived, but different patterns of aromatase minor transcripts were found: promoter I.3- and I.6-derived transcripts were identified in the tumor, while only promoter I.4-derived transcripts were found in normal adrenal. This case report demonstrates that a sharp aromatase overexpression is not a prerequisite for clinical and biochemical hyperestrogenism, and further characterizes the aromatase promoter utilization in this feminizing adrenocortical tumor and in the normal adrenal cortex.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Biologie de la reproduction / Reproduction sexuée

Sciences du Vivant [q-bio] / Biologie cellulaire / Interactions cellulaires [q-bio.CB]

Sciences du Vivant [q-bio] / Biochimie, Biologie Moléculaire / Biologie moléculaire

Liste complète des métadonnées

https://hal-normandie-univ.archives-ouvertes.fr/hal-02154099
Contributeur : Hélène Bouraïma-Lelong <>
Soumis le : mercredi 12 juin 2019 - 16:53:55
Dernière modification le : mercredi 12 juin 2019 - 17:36:10

Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme.

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Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme.

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