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Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme.

Abstract : A 30-year-old male was referred for the rapid development of gynecomastia, and dramatic hyperestrogenemia was assessed: plasma estrone, estradiol but also cortisol were not suppressed by high-dose dexamethasone, while gonadotropin pulsatility was completely abolished. A 60-mm right adrenal tumor was evidenced on computed tomography-scan, and the patient underwent adrenalectomy. The tumor was found to express a moderate increase in aromatase activity compared with adjacent non-neoplastic adrenal tissue. Quantitative RT-PCR also showed a weak and non-significant increase in total aromatase mRNA in the tumor compared with normal adrenal tissue. Aromatase transcripts were mainly promoter PII-derived, but different patterns of aromatase minor transcripts were found: promoter I.3- and I.6-derived transcripts were identified in the tumor, while only promoter I.4-derived transcripts were found in normal adrenal. This case report demonstrates that a sharp aromatase overexpression is not a prerequisite for clinical and biochemical hyperestrogenism, and further characterizes the aromatase promoter utilization in this feminizing adrenocortical tumor and in the normal adrenal cortex.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02154099
Contributor : Hélène Bouraïma-Lelong <>
Submitted on : Wednesday, June 12, 2019 - 4:53:55 PM
Last modification on : Monday, April 27, 2020 - 4:24:01 PM

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Hélène Bouraïma Lelong, Barabara Lireux, Hervé Mittre, Annie Benhaim, Michel Herrou, et al.. Major hyperestrogenism in a feminizing adrenocortical adenoma despite a moderate overexpression of the aromatase enzyme.. European Journal of Endocrinology, BioScientifica, 2003, 148 (4), pp.457-461. ⟨10.1530/eje.0.1480457⟩. ⟨hal-02154099⟩

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