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Differential effects of bisphenol A and estradiol on rat spermatogenesis’ establishment

Abstract : Several studies have highlighted the negative effects of bisphenol A (BPA), a chemical compound with estrogenic activity, on reproductive health. To elucidate the impact of BPA on spermatogenesis' establishment and mechanisms of action of BPA and 17β-estradiol (E2), as both can be found in the environment, we exposed rats to BPA (50μg/kg bw/day of BPA), E2 (20μg/kg bw/day of E2) and BPA+E2 from 15 to 30days post-partum. Histological and gene expression studies revealed that BPA and BPA+E2 exposures promoted spermatogenesis establishment whereas E2 alone delayed it. Then, a decrease in gene expression of blood-testis-barrier (BTB) proteins was observed in all treated groups. Therefore, our study has demonstrated a differential effect of BPA and E2 exposures on spermatogenesis establishment in prepubertal rats and a deleterious effect of these chemicals on BTB establishment. Thus, the effects of BPA seem to be mediated by receptors other than estrogen receptors.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02154033
Contributor : Hélène Bouraïma-Lelong <>
Submitted on : Wednesday, June 12, 2019 - 4:16:13 PM
Last modification on : Friday, May 29, 2020 - 3:33:41 AM

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Vanessa Brouard, Isabelle Guenon, Hélène Bouraïma-Lelong, Christelle Delalande. Differential effects of bisphenol A and estradiol on rat spermatogenesis’ establishment. Reproductive Toxicology, Elsevier, 2016, 63, pp.49-61. ⟨10.1016/j.reprotox.2016.05.003⟩. ⟨hal-02154033⟩

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