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Acute effect of bisphenol A: Signaling pathways on calcium influx in immature rat testes

Abstract : We investigated the acute effect of low concentrations of BPA on calcium influx and the mechanism of action of BPA in this rapid response in the rat testis. BPA increased calcium influx at 1 pM and 1 nM at 300 s of incubation, in a similar manner to that of estradiol. At 1 pM, BPA stimulated calcium influx independently of classical estrogen receptors, consistent with a G-protein coupled receptor. This effect also involves the modulation of ionic channels, such as K+, TRPV1 and Cl- channels. Furthermore, BPA is able to modulate calcium from intracellular storages by inhibiting SERCA and activating IP3 receptor/Ca2+ channels at the endoplasmic reticulum and activate kinase proteins, such as PKA and PKC. The rapid responses of BPA on calcium influx could, in turn, trigger a cross talk by MEK and p38MAPK activation and also mediate genomic responses.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02153854
Contributor : Hélène Bouraïma-Lelong <>
Submitted on : Wednesday, June 12, 2019 - 3:32:53 PM
Last modification on : Thursday, May 28, 2020 - 8:22:02 PM

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Renata Goncalves, Ana Paula Zanatta, Fernanda Carvalho Cavalari, Monica Andressa Wessner Do Nascimento, Christelle Delalande-Lecapitaine, et al.. Acute effect of bisphenol A: Signaling pathways on calcium influx in immature rat testes. Reproductive Toxicology, Elsevier, 2018, 77, pp.94-102. ⟨10.1016/j.reprotox.2018.02.009⟩. ⟨hal-02153854⟩

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