 |
Journal articles
Hypoglycemic Toxins and Enteroviruses as Causes of Outbreaks of Acute Encephalitis-Like Syndrome in Children, Bac Giang Province, Northern Vietnam
Abstract : We investigated the cause of seasonal outbreaks of pediatric acute encephalitis-like syndrome associated with litchi harvests (May-July) in northern Vietnam since 2008. Nineteen cerebrospinal fluid samples were positive for human enterovirus B, and 8 blood samples were positive for hypoglycemic toxins present in litchi fruits. Patients who were positive for hypoglycemic toxins had shorter median times between disease onset and admission, more reports of seizures, more reports of hypoglycemia (glucose level <3 mmol/L), lower median numbers of leukocytes in cerebrospinal fluid, and higher median serum levels of alanine aminotransferase and aspartate transaminase than did patients who were positive for enteroviruses. We suggest that children with rapidly progressing acute encephalitis-like syndrome at the time of the litchi harvest have intoxication caused by hypoglycemic toxins, rather than viral encephalitis, as previously suspected. These children should be urgently treated for life-threatening hypoglycemia.
Cited literature [45 references]
https://hal-normandie-univ.archives-ouvertes.fr/hal-02146362
Contributor : Meriadeg Le Gouil Connect in order to contact the contributor
Submitted on : Thursday, June 13, 2019 - 6:35:04 PM
Last modification on : Friday, August 5, 2022 - 2:54:00 PM
Contributor : Meriadeg Le Gouil Connect in order to contact the contributor
Submitted on : Thursday, June 13, 2019 - 6:35:04 PM
Last modification on : Friday, August 5, 2022 - 2:54:00 PM
