Resolution of an atropoisomeric naphthamide by second-order asymmetric transformation: A highly productive technique

Ryusei Oketani; Marine Hoquante; Clément Brandel; Pascal Cardinaël; Gérard Coquerel

Resolution of an atropoisomeric naphthamide by second-order asymmetric transformation: A highly productive technique

Ryusei Oketani ¹ Marine Hoquante ¹ Clément Brandel ¹ Pascal Cardinaël ¹ Gérard Coquerel ¹

1 SMS - Sciences et Méthodes Séparatives

Abstract : Temperature-cycle-induced deracemization (TCID) has been widely studied in the field of chiral separation, ranging from fundamental research to applications. In this study, the second-order asymmetric transformation (SOAT) of 2-methoxy-1-naphthamide in an azeotropic mixture of ethyl acetate and cyclohexane is compared with TCID, in terms of process productivity. The results indicate that the volumetric productivity using SOAT was over 100-times higher than that using TCID, such that a scale-up by a factor of 10 was easily implemented.

Keywords : deracemization second-order asymmetric transformation (SOAT) productivity atropisomerism 2

Type de document :

Article dans une revue

Domaine :

Sciences de l'ingénieur [physics] / Matériaux

Chimie / Chimie inorganique

Chimie / Cristallographie

Chimie / Chimie organique

Liste complète des métadonnées

Littérature citée [52 références] Voir Masquer Télécharger

https://hal-normandie-univ.archives-ouvertes.fr/hal-02138812
Contributeur : Clément Brandel <>
Soumis le : mardi 3 septembre 2019 - 10:07:07
Dernière modification le : jeudi 24 octobre 2019 - 15:32:07

Resolution of an atropoisomeric naphthamide by second-order asymmetric transformation: A highly productive technique

Fichier

Accès restreint

Identifiants

Collections

Citation

Exporter

Métriques

42

Resolution of an atropoisomeric naphthamide by second-order asymmetric transformation: A highly productive technique

Fichier

Accès restreint

Identifiants

Collections

Citation

Exporter

Partager

Métriques

42