Skip to Main content Skip to Navigation
Journal articles

Near-Infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain

Abstract : Little is known about cerebral blood flow, cerebral blood volume (CBV), oxygenation, and oxygen consumption in the premature newborn brain. We combined quantitative frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation (SO(2)) and CBV with diffusion correlation spectroscopy measures of cerebral blood flow index (BF(ix)) to determine the relationship between these measures, gestational age at birth (GA), and chronological age. We followed 56 neonates of various GA once a week during their hospital stay. We provide absolute values of SO(2) and CBV, relative values of BF(ix), and relative cerebral metabolic rate of oxygen (rCMRO(2)) as a function of postmenstrual age (PMA) and chronological age for four GA groups. SO(2) correlates with chronological age (r=-0.54, P value ≤0.001) but not with PMA (r=-0.07), whereas BF(ix) and rCMRO(2) correlate better with PMA (r=0.37 and 0.43, respectively, P value ≤0.001). Relative CMRO2 during the first month of life is lower when GA is lower. Blood flow index and rCMRO(2) are more accurate biomarkers of the brain development than SO(2) in the premature newborns.
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-02135225
Contributor : Nadege Roche-Labarbe <>
Submitted on : Tuesday, May 21, 2019 - 10:20:16 AM
Last modification on : Wednesday, May 22, 2019 - 2:20:23 PM

Links full text

Identifiers

Collections

Citation

Nadege Roche-Labarbe, Angela Fenoglio, Alpna Aggarwal, Mathieu Dehaes, Stefan Carp, et al.. Near-Infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature Brain. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2012, 32 (3), pp.481-488. ⟨10.1038/jcbfm.2011.145⟩. ⟨hal-02135225⟩

Share

Metrics

Record views

43