Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm, Plant Physiol, vol.136, pp.3457-3466, 2004. ,
On-chip detection of low-molecular-weight recombinant proteins in plant crude extracts by SELDI TOF MS, Methods Biotechnol, 2008. ,
A SELDI TOF MS procedure for the detection, quantitation and preliminary characterization of low-molecular-weight recombinant proteins expressed in transgenic plants, Proteomics, 2008. ,
Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xylose, Glycobiology, vol.13, pp.427-434, 2003. ,
Furinmediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors, Proc. Natl. Acad. Sci. USA, 97, vol.11, pp.905-916, 2000. ,
Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 Å resolution and its comparison with other serpins, J. Mol. Biol, vol.218, pp.595-606, 1991. ,
The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis, Phytochemistry, vol.65, pp.43-58, 2004. ,
Preventing unintended proteolysis in plant protein biofactories, Plant Biotechnol. J, vol.6, pp.633-648, 2008. ,
Companion protease inhibitors to protect recombinant proteins in transgenic plant extracts, Methods Biotechnol, 2008. ,
Nucleocytoplasmic transit of human ? 1 -antichymotrypsin in tobacco leaf epidermal cells, Plant Biotechnol. J, 2008. ,
Production of recombinant serpins in Escherichia coli, Method, vol.32, pp.169-176, 2004. ,
Latent alpha1-antichymotrypsin. A molecular explanation for the inactivation of alpha1-antichymotrypsin in chronic bronchitis and emphysema, J. Biol. Chem, vol.273, pp.3695-3701, 1998. ,
Localization of a bacterial protein in starch granules of transgenic maize kernels, Proc. Natl. Acad. Sci. USA, vol.100, pp.127-138, 2003. ,
Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity, Plant Mol. Biol, vol.38, pp.101-109, 1998. ,
Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants, Trends Plant Sci, vol.6, pp.219-226, 2001. ,
Foreign protein degradation and instability in plants and plant tissue cultures, Trends Biotechnol, vol.24, pp.426-432, 2006. ,
The intracellular fate of a recombinant protein is tissue dependent, Plant Physiol, vol.141, pp.578-586, 2006. ,
Selection of antibodies specific for fucose or xylose containing N-linked glycans from higher plants, Anal. Biochem, vol.209, pp.104-108, 1993. ,
Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming, Vaccine, vol.23, pp.1770-1778, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-01942853
, Serpins: Structure, Function and Biology, 1996.
Posttranslational modification of therapeutic proteins in plants, Curr. Opin. Plant Biol, vol.7, pp.171-181, 2004. ,
The C-terminal HDEL sequence is sufficient for retention of secretory proteins in the endoplasmic reticulum (ER) but promotes vacuolar targeting of proteins that escape the ER, Plant J, vol.11, pp.313-325, 1997. ,
Production of foreign proteins in tobacco cell suspension culture, Methods Biotechnol, vol.3, pp.155-164, 1998. ,
Production and glycosylation of plant-made pharmaceuticals: The antibodies as a challenge, Plant Biotechnol. J, vol.2, pp.83-100, 2004. ,
Biopharmaceutical production in plants: problems, solutions and opportunities, Trends Biotechnol, vol.23, pp.559-565, 2005. ,
Degradation and stabilization of recombinant proteins in plants, Floriculture, Ornamental and Plant Biotechnology, vol.IV, pp.35-40, 2006. ,
Plant cell cultures for the production of recombinant proteins, Nat. Biotechnol, vol.22, pp.1415-1422, 2004. ,
Retention of maize auxin-binding protein in the endoplasmic reticulum: quantifying escape and the role of auxin, Planta, vol.202, pp.313-323, 1997. ,
Role of sugar chains in the expression of the biological activity of human erythropoietin, J. Biol. Chem, vol.267, pp.7703-7709, 1992. ,
Expression and purification of functional human alpha-1-antitrypsin from cultured plant cells, Biotechnol. Progr, vol.17, pp.126-133, 2001. ,
) ? 1 -Antichymotrypsin, Int. J. Biochem. Cell Biol, vol.28, pp.961-964, 1996. ,
Modulating the proteinase inhibitory profile of a plant cystatin by single mutations at positively selected amino acid sites, Plant J, vol.48, pp.403-413, 2006. ,
Function and glycosylation of plant-derived antiviral monoclonal antibody, Proc. Natl. Acad. Sci. USA, vol.100, pp.8013-8018, 2003. ,
Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots, Plant Physiol, vol.141, pp.1185-1193, 2006. ,
Effect of glycosylation on the stability of alpha1-antitrypsin toward urea denaturation and thermal deactivation, Biochim. Biophys. Acta, vol.1335, pp.265-272, 1997. ,
Refolding of alpha 1-antitrypsin expressed as inclusion bodies in Escherichia coli: characterization of aggregation, Biochim. Biophys. Acta, vol.1247, pp.179-184, 1995. ,
Purification and characterization of alpha 1-antitrypsin secreted by recombinant yeast Saccharomyces diastaticus, J. Biotechnol, vol.42, pp.191-195, 1995. ,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, vol.227, pp.680-685, 1970. ,
Expression of active human C1 inhibitor serpin domain in Escherichia coli, Protein Expr. Purif, vol.22, pp.349-358, 2001. ,
N-glycoprotein biosynthesis in plants: recent developments and future trends, Plant Mol. Biol, vol.38, pp.31-48, 1998. ,
Suspension-cultured BY-2 tobacco cells produce and mature immunologically active house dust mite allergens, Plant Biotechnol. J, vol.5, pp.93-108, 2007. ,
The production of recombinant pharmaceutical proteins in plants, Nat. Rev. Genet, vol.4, pp.794-805, 2003. ,
Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling, Curr. Genet, vol.45, pp.231-260, 2004. ,
Production of oryzacystatins I and II in Escherichia coli using the glutathione Stransferase gene fusion system, Biotechnol. Progr, vol.10, pp.155-159, 1994. ,
The role of sialic acid in the functional activity and the hepatic clearance of C1-INH, J. Immunol, vol.126, pp.245-249, 1981. ,
Identification of lysines within alpha 1-antichymotrypsin important for DNA binding. An unusual combination of DNAbinding elements, J. Biol. Chem, vol.270, pp.548-562, 1995. ,
A short C-terminal sequence is necessary and sufficient for the targeting of chitinases to the plant vacuole, Proc. Natl. Acad. Sci. USA, vol.88, pp.362-372, 1991. ,
A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells, Plant Biotechnol. J, vol.3, pp.115-127, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00080329
Posttranslational removal of the carboxyl-terminal KDEL of the cysteine protease SH-EP occurs prior to maturation of the enzyme, J. Biol. Chem, vol.274, pp.390-401, 1999. ,
Fusion with HDEL protects cell wall invertase from early degradation when N-glycosylation is inhibited, Plant Cell Physiol, vol.44, pp.173-182, 2003. ,
Mechanisms of receptormediated nuclear import and nuclear export, Traffic, vol.6, pp.187-198, 2005. ,
Codon-modifications and an endoplasmic reticulum-targeting sequence additively enhance expression of an Aspergillus phytase gene in transgenic canola, Plant Cell Rep, vol.25, pp.124-132, 2006. ,
A KDEL-tagged monoclonal antibody is efficiently retained in the endoplasmic reticulum in leaves, but is both partially secreted and sorted to protein storage vacuoles in seeds, Plant Biotechnol. J, vol.4, pp.511-527, 2006. ,
Proteolytic inactivation of alpha-1-anti-chymotrypsin. Sites of cleavage and generation of chemotactic activity, J. Biol. Chem, vol.266, pp.482-503, 1991. ,
Effects of glycosylation on the folding and stability of human, recombinant and cleaved alpha 1-antitrypsin, J. Mol. Biol, vol.224, pp.241-252, 1992. ,
Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens, J. Biol. Chem, vol.275, pp.451-462, 2000. ,
An in-built proteinase inhibitor system for the protection of recombinant proteins recovered from transgenic plants, Plant Biotechnol. J, vol.4, pp.359-368, 2006. ,
The biology and biochemistry of antichymotrypsin and its potential role as a therapeutic agent, Biol. Chem. HoppeSeyler, vol.373, pp.497-502, 1992. ,
Cloning, expression, purification, and biological activity of recombinant native and variant human ? 1 -antichymotrypsins, J. Biol. Chem, vol.265, pp.1199-1207, 1990. ,
Conversion of alpha 1-antichymotrypsin into a human neutrophil elastase inhibitor: demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities, Biochemistry, vol.33, pp.7627-7633, 1994. ,
Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta), Pharm. Res, vol.15, pp.641-649, 1998. ,
From planta to pharma with glycosylation in the toolbox, Trends Biotechnol, vol.25, pp.317-323, 2007. ,
A cut above the rest: the regulatory function of plant proteases, Planta, vol.220, pp.183-197, 2004. ,
On the size of the active site in proteases, I. Papain. Biochem. Biophys. Res. Commun, vol.27, pp.157-162, 1967. ,
Production of Desmodus rotundus salivary plasminogen activator alpha1 (DSPAalpha1) in tobacco is hampered by proteolysis, Biotechnol. Bioeng, vol.89, pp.848-858, 2005. ,
Endoplasmic reticulumassociated degradation: exceptions to the rule, Eur. J. Cell Biol, vol.83, pp.501-509, 2004. ,
Challenges in therapeutic glycoprotein production, Curr. Opin. Biotechnol, vol.17, pp.341-346, 2006. ,
Molecular cloning of a putative plant endomembrane protein resembling vertebrate protein disulfideisomerase and a phosphatidylinositol-specific phospholipase C, Proc. Natl. Acad. Sci. USA, vol.88, pp.941-951, 1991. ,
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins -evolution, mechanism of inhibition, novel functions, and a revised nomenclature, J. Biol. Chem, vol.276, pp.293-326, 2001. ,
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase, Gene, vol.67, pp.31-40, 1988. ,
A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells, Proc. Natl. Acad. Sci. USA, vol.100, pp.2209-2214, 2003. ,
Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues, Plant Biotechnol. J, vol.2, pp.279-287, 2004. ,
What do dysfunctional serpins tell us about molecular mobility and disease?, Nat. Struct. Biol, vol.2, pp.96-113, 1995. ,
DOI : 10.1038/nsb0295-96
Practical considerations for pharmaceutical antibody production in different crop systems, Mol. Breed, vol.9, pp.149-158, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-00086176
Approaches to achieve high-level heterologous protein production in plants, Plant Biotechnol. J, vol.5, pp.2-15, 2007. ,
Analysis of the tissue and cellular localization of alpha-1-antichymotrypsin by an immunohistochemical technique, Gann, vol.73, pp.742-747, 1982. ,
Incorporation of alpha-1-antichymotrypsin into carcinoma cell nuclei of human stomach adenocarcinoma transplanted into nude mice, Cancer Res, vol.46, pp.3688-3691, 1986. ,
Effect of osmotic pressure on human alpha(1)-antitrypsin production by plant cell culture, Biochem. Eng. J, vol.4, pp.31-36, 1999. ,
Production of functional human alpha 1-antitrypsin by plant cell culture, Appl. Microbiol. Biotechnol, vol.52, pp.516-523, 1999. ,
Isolation and properties of recombinant DNA produced variants of human alpha 1-proteinase inhibitor, J. Biol. Chem, vol.260, pp.4384-4389, 1985. ,
Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds, Proc. Natl. Acad. Sci. USA, vol.104, pp.1430-1435, 2007. ,
Post-translational modifications in the context of therapeutic proteins, Nat. Biotechnol, vol.24, pp.1241-1252, 2006. ,
Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop, Nat. Struct. Biol, vol.1, pp.251-258, 1994. ,
Select what you need: a comparative evaluation of the advantages and limitations of frequently used expression systems for foreign genes, J. Biotechnol, vol.127, pp.335-347, 2007. ,
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry, Nat. Biotechnol, vol.21, pp.660-666, 2003. ,