BiCl 3 -Mediated direct functionalization of unsaturated C–C bonds with an electrophilic SCF 2 PO(OEt) 2 reagent

Jianjun Wang (1) , Heng-Ying Xiong (1) , Emilie Petit (1) , Laëtitia Bailly (1) , Xavier Pannecoucke (1) , Thomas Poisson (1) , Tatiana Besset (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

A transition metal-free approach was developed for the direct difunctionalization of disubstituted alkynes and terminal alkenes with concomitant formation of C–SCF2PO(OEt)2 and C–Cl bonds. The BiCl3-mediated reaction offered access to high value-added functionalized scaffolds in a single operation under mild conditions. Extension to SCF2PO(OEt)2-containing alkynes was also studied.

Domains: Chemical Sciences; Organic chemistry

Jianjun Wang, Heng-Ying Xiong, Emilie Petit, Laëtitia Bailly, Xavier Pannecoucke, et al.. BiCl 3 -Mediated direct functionalization of unsaturated C–C bonds with an electrophilic SCF 2 PO(OEt) 2 reagent. Chemical Communications, 2019, 55 (60), pp.8784-8787. ⟨10.1039/c9cc01851d⟩. ⟨hal-02121245⟩