Delayed Pituitary Adenylate Cyclase–Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization

Coralie Brifault , Marjorie Gras (1) , Donovan Liot , Victor May (2) , David Vaudry (3) , Olivier Wurtz (4)

1 Neuroendocrinologie cellulaire et moléculaire
2 University of Vermont College of Medicine
3 International Associated laboratory Samuel de Champlain
4 DC2N - Différenciation et communication neuronale et neuroendocrine

Until now, except thrombolysis, the therapeutical strategies targeting the acute phase of cerebral ischemia have been proven ineffective, and no approach is available to attenuate the delayed cell death mechanisms and the resulting functional deficits in the late phase. Then, we investigated whether a targeted and delayed delivery of pituitary adenylate cyclase-activating polypeptide (PACAP), a peptide known to exert neuroprotective activities, may dampen delayed pathophysiological processes improving functional recovery.

Keywords: inflammation; microglia; pituitary adenylate cyclase-activating polypeptide; stroke

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology; Life Sciences [q-bio]; Immunology; Innate immunity; Life Sciences [q-bio]; Immunology; Adaptive immunology

Coralie Brifault, Marjorie Gras, Donovan Liot, Victor May, David Vaudry, et al.. Delayed Pituitary Adenylate Cyclase–Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization. Stroke, 2015, 46 (2), pp.520-528. ⟨10.1161/STROKEAHA.114.006864⟩. ⟨hal-02058106⟩