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Journal articles
Pd-catalyzed diastereoselective trifluoromethylthiolation of functionalized acrylamides
Abstract : The Pd-catalyzed diastereoselective trifluoromethylthiolation of acrylamides was developed to allow the formation of the Z-isomer as a single product. Using a C–H bond functionalization strategy, the method was applied to a broad range of α-aryl, α-alkyl, and α,β-disubstituted acrylamides bearing the amide derived from the 8-aminoquinoline as a directing group. Mechanistic studies as well as postfunctionalization of the products were performed. This approach opens new routes to unprecedented SCF3-containing scaffolds.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02046318
Contributor : Madeleine Roux-Merlin Connect in order to contact the contributor
Submitted on : Friday, February 22, 2019 - 3:40:31 PM
Last modification on : Tuesday, October 19, 2021 - 11:34:47 PM
Contributor : Madeleine Roux-Merlin Connect in order to contact the contributor
Submitted on : Friday, February 22, 2019 - 3:40:31 PM
Last modification on : Tuesday, October 19, 2021 - 11:34:47 PM
