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Pd-Catalyzed Regioselective Decarboxylative/C–H α-Alkoxyalkenylation of Heterocycles Using α-Carboxyvinylethers

Abstract : A direct introduction of vinyl ethers into C–H bond of heterocycles is reported. For this purpose, decarboxylative direct C–H cross-coupling of 1,3-diazoles with α-carboxyvinyl ethers as coupling partners was achieved under Pd(0)/Cu(I) cooperative catalysis to produce various α-heteroarylated vinylethers. This methodology was applied to the innovative production of heteroarylated enolizable ketones and naturally occurring bis-oxa(thia)zoles.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02046307
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:40:20 PM
Last modification on : Thursday, July 2, 2020 - 3:29:21 AM

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Jean-Baptiste Rouchet, M. Hachem, Cédric Schneider, Christophe Hoarau. Pd-Catalyzed Regioselective Decarboxylative/C–H α-Alkoxyalkenylation of Heterocycles Using α-Carboxyvinylethers. ACS Catalysis, American Chemical Society, 2017, 7 (8), pp.5363-5369. ⟨10.1021/acscatal.7b01330⟩. ⟨hal-02046307⟩

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