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Structure-efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds

Abstract : New derivatives of cyclodextrins were prepared in order to determine the relative importance of the structural key elements involved in the degradation of organophosphorus nerve agents. To avoid a competitive inclusion between the organophosphorus substrate and the iodosobenzoate group, responsible for its degradation, the latter group had to be covalently bound to the cyclodextrin scaffold. Although the presence of the α nucleophile iodosobenzoate was a determinant in the hydrolysis process, an imidazole group was added to get a synergistic effect towards the degradation of the agents. The degradation efficiency was found to be dependent on the relative position of the heterocycle towards the reactive group as well as on the nature of the organophosphorus derivative.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02046294
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:40:07 PM
Last modification on : Thursday, July 2, 2020 - 3:28:30 AM

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Sophie Letort, Michaël Bosco, Benedetta Cornelio, Frédérique Brégier, Sébastien Daulon, et al.. Structure-efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2017, 13, pp.417-427. ⟨10.3762/bjoc.13.45⟩. ⟨hal-02046294⟩

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