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Journal articles
Structure-efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds
Abstract : New derivatives of cyclodextrins were prepared in order to determine the relative importance of the structural key elements involved in the degradation of organophosphorus nerve agents. To avoid a competitive inclusion between the organophosphorus substrate and the iodosobenzoate group, responsible for its degradation, the latter group had to be covalently bound to the cyclodextrin scaffold. Although the presence of the α nucleophile iodosobenzoate was a determinant in the hydrolysis process, an imidazole group was added to get a synergistic effect towards the degradation of the agents. The degradation efficiency was found to be dependent on the relative position of the heterocycle towards the reactive group as well as on the nature of the organophosphorus derivative.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02046294
Contributor : Madeleine Roux-Merlin Connect in order to contact the contributor
Submitted on : Friday, February 22, 2019 - 3:40:07 PM
Last modification on : Wednesday, December 1, 2021 - 2:42:17 PM
Contributor : Madeleine Roux-Merlin Connect in order to contact the contributor
Submitted on : Friday, February 22, 2019 - 3:40:07 PM
Last modification on : Wednesday, December 1, 2021 - 2:42:17 PM
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