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Article Dans Une Revue European Journal of Organic Chemistry Année : 2017

Copper‐Mediated [(Diethylphosphono)difluoromethyl]thiolation of α‐Bromo Ketones

Résumé

We report herein a straightforward access to α‐[(diethoxyphosphoryl)difluoromethyl]thiolated ketones. The methodology, which involves the nucleophilic [Cu]CF2PO(OEt)2 species, has allowed the formation of the targeted compounds in moderate to high yields by using a simple procedure. This method represents a convenient alternative to the known approaches for the introduction of this emergent fluorinated motif.

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Chimie
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Dates et versions

hal-02046282 , version 1 (22-02-2019)

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Citer

Maria V. Ivanova, Alexandre Bayle, Tatiana Besset, Xavier Pannecoucke, Thomas Poisson. Copper‐Mediated [(Diethylphosphono)difluoromethyl]thiolation of α‐Bromo Ketones. European Journal of Organic Chemistry, 2017, 2017 (17), pp.2475-2480. ⟨10.1002/ejoc.201700182⟩. ⟨hal-02046282⟩
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