Copper‐Mediated [(Diethylphosphono)difluoromethyl]thiolation of α‐Bromo Ketones

Abstract : We report herein a straightforward access to α‐[(diethoxyphosphoryl)difluoromethyl]thiolated ketones. The methodology, which involves the nucleophilic [Cu]CF2PO(OEt)2 species, has allowed the formation of the targeted compounds in moderate to high yields by using a simple procedure. This method represents a convenient alternative to the known approaches for the introduction of this emergent fluorinated motif.