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Copper‐Mediated [(Diethylphosphono)difluoromethyl]thiolation of α‐Bromo Ketones

Maria V. Ivanova 1 Alexandre Bayle 1 Tatiana Besset 1 Xavier Pannecoucke 1 Thomas Poisson 1
1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
Abstract : We report herein a straightforward access to α‐[(diethoxyphosphoryl)difluoromethyl]thiolated ketones. The methodology, which involves the nucleophilic [Cu]CF2PO(OEt)2 species, has allowed the formation of the targeted compounds in moderate to high yields by using a simple procedure. This method represents a convenient alternative to the known approaches for the introduction of this emergent fluorinated motif.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02046282
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:39:52 PM
Last modification on : Wednesday, July 8, 2020 - 2:14:02 PM

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Maria V. Ivanova, Alexandre Bayle, Tatiana Besset, Xavier Pannecoucke, Thomas Poisson. Copper‐Mediated [(Diethylphosphono)difluoromethyl]thiolation of α‐Bromo Ketones. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2017, 2017 (17), pp.2475-2480. ⟨10.1002/ejoc.201700182⟩. ⟨hal-02046282⟩

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