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18F-Fluoroform: A 18F-trifluoromethylating agent for the synthesis of SCF2 18F-aromatic derivatives

Elodie Carbonnel 1 Tatiana Besset 1 Thomas Poisson 1 Daniel Labar Xavier Pannecoucke 1 Philippe Jubault 1
1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
Abstract : Herein the synthesis of various SCF218F-containing derivatives is reported by a transition metal-free process. By using HCF218F, readily generated from a bench-stable difluoromethyl sulfonium salt, various aromatic disulfides were easily converted into the desired radiolabelled trifluoromethylthiolated compounds in the presence of a base. This protocol allowed the formation of the SCF218F-containing aromatic derivatives in good to excellent radiochemical yields. This process was also extended to the corresponding selenium derivative.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02046267
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:39:35 PM
Last modification on : Thursday, July 2, 2020 - 3:30:02 AM

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CNRS | COBRA | UNIROUEN | COMUE-NORMANDIE | INSA-ROUEN | INC-CNRS | INSA-GROUPE | ENSICAEN | UNILEHAVRE | UNICAEN

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Elodie Carbonnel, Tatiana Besset, Thomas Poisson, Daniel Labar, Xavier Pannecoucke, et al.. 18F-Fluoroform: A 18F-trifluoromethylating agent for the synthesis of SCF2 18F-aromatic derivatives. Chemical Communications, Royal Society of Chemistry, 2017, 53 (42), pp.5706-5709. ⟨10.1039/c7cc02652h⟩. ⟨hal-02046267⟩

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