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An Overview of the Synthesis of Highly Versatile N-Hydroxysuccinimide Esters

Abstract : N-Hydroxysuccinimide esters (NHS-esters) are important and widely used tools in various areas of chemistry including peptide synthesis, bioconjugate chemistry, functionalized materials and polymers. The usual strategy employed to prepare these active esters generally relies on the coupling reaction with a carboxylic acid and N-hydroxysuccinimide in the presence of a coupling agent. However, more recently, many other efficient strategies have emerged in the literature. This short review covers the literature devoted to the preparation of these valuable N-hydroxysuccinimide esters.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02046258
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:39:26 PM
Last modification on : Thursday, July 2, 2020 - 3:28:17 AM

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Anaïs Barré, Mihaela-Liliana Tîntas, Vincent Levacher, Cyril Papamicaël, Vincent Gembus. An Overview of the Synthesis of Highly Versatile N-Hydroxysuccinimide Esters. SYNTHESIS, Georg Thieme Verlag, 2017, 49 (3), pp.472-483. ⟨10.1055/s-0036-1588607⟩. ⟨hal-02046258⟩

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