Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones

J. Annibaletto , Sylvain Oudeyer (1) , Vincent Levacher (1) , Jean-François Brière (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

This short review provides an overview concerning the developments toward the catalytic enantioselective syntheses of isoxazolidin-5-one derivatives making use of metal-based or organocatalytic conditions. The subsequent use and chemical transformations of these valuable chiral oxazole heterocycles will also be described.

Keywords: Meldrum’s acid; Asymmetric catalysis; Organometallics; Organocatalysis; Isoxazolidinones

Domains: Chemical Sciences

J. Annibaletto, Sylvain Oudeyer, Vincent Levacher, Jean-François Brière. Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones. Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (10), pp.2117-2128. ⟨10.1055/s-0036-1588765⟩. ⟨hal-02046255⟩