Skip to Main content Skip to Navigation
Journal articles

An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2Group to Molecules

Abstract : An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF2PO(OEt)2) was designed. Under mild and metal‐free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C−SCF2PO(OR)2, N−SCF2PO(OR)2, and S−SCF2PO(OR)2 bonds. Finally, thanks to this new methodology, the synthesis of the non‐stereoidal anti‐inflammatory diflumidone was achieved.
Document type :
Journal articles
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-02046245
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:37:30 PM
Last modification on : Wednesday, July 8, 2020 - 2:14:02 PM

Links full text

Identifiers

Citation

Heng-Ying Xiong, Alexandre Bayle, Xavier Pannecoucke, Tatiana Besset. An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2Group to Molecules. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2016, 55 (43), pp.13490-13494. ⟨10.1002/anie.201607231⟩. ⟨hal-02046245⟩

Share

Metrics

Record views

67