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Mild, Efficient, One-Pot Synthesis of Imidazolones Promoted by N,O-Bistrimethylsilylacetamide (BSA)

Abstract : The formation of imidazolones by means of dehydrative cyclization was developed, using bistrimethylsilylacetamide. This highly versatile, friendly, safe, and cost-effective reagent exhibited a very large scope of starting materials, since it can promote the formation of 4-benzylidene imidazolones, 4,4-dialkyl-imidazolones, bearing alkyl, aryl, or even no substituent at C2, the latter being unavailable by classical methods. This reagent also afforded clean and high-yielding one-pot reactions in the presence of amine or imine reagents.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02046228
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:37:04 PM
Last modification on : Thursday, July 2, 2020 - 3:29:08 AM

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M. Muselli, L. Colombeau, J. Hédouin, Christophe Hoarau, Laurent Bischoff. Mild, Efficient, One-Pot Synthesis of Imidazolones Promoted by N,O-Bistrimethylsilylacetamide (BSA). SYNLETT, Georg Thieme Verlag, 2016, 27 (20), pp.2819-2825. ⟨10.1055/s-0035-1562524⟩. ⟨hal-02046228⟩

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