Ionic liquids and cyclodextrin inclusion complexes: limitation of the affinity capillary electrophoresis technique

Nadine Mofaddel (1) , Sophie Fourmentin (2) , F. Guillen (1, 3) , David Landy (2) , Géraldine Gouhier (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 UCEIV - Unité de Chimie Environnementale et Interactions sur le Vivant
3 SPCMIB - Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique

The state of the art of inclusion complex formation between cyclodextrins and ionic liquids is reported. Mechanisms, stoichiometries, and binding constants are summarized and classified by anion. We investigated the supramolecular interactions between the β-cyclodextrin cavity and six ionic liquids based on 1-dodecyl-3-methylimidazolium by affinity capillary electrophoresis and compared the results with those obtained by isothermal titration calorimetry. We show that the presence of basic or acidic buffers leads to a metathesis reaction, underlining the limitation of the affinity capillary electrophoresis technique.

Keywords: Isothermal titration calorimetry; Cyclodextrin; Affinity capillary electrophoresis; Ionic liquid; Binding constants

Domains: Chemical Sciences

Nadine Mofaddel, Sophie Fourmentin, F. Guillen, David Landy, Géraldine Gouhier. Ionic liquids and cyclodextrin inclusion complexes: limitation of the affinity capillary electrophoresis technique. Analytical and Bioanalytical Chemistry, 2016, 408 (28), pp.8211-8220. ⟨10.1007/s00216-016-9931-z⟩. ⟨hal-02046227⟩