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Efficient Microwave-Assisted Synthesis of Methyl 4- or 5-Nitro­anthranilate

Julien Godeau 1 Anthony Martinet 2 Vincent Levacher 1 Corinne Fruit 1 Thierry Besson 1
1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 Anton Paar France
Abstract : A novel method for the synthesis of anthranilate esters is described. The esterification reaction of nitro-substituted anthranilic acids was carried out under microwave irradiation. A range of solvents and other reaction parameters were investigated to provide the most environmentally friendly reaction conditions. The feasibility of scale-up was demonstrated, allowing a simple and inexpensive production of anthranilate esters.
Keywords : Hydrolysis Microwave chemistry Green solvent Sustainable chemistry One-pot reactions
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Journal articles
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02046207
Contributor : Madeleine Roux-Merlin <>
Submitted on : Friday, February 22, 2019 - 3:36:36 PM
Last modification on : Thursday, July 2, 2020 - 3:29:32 AM

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UNIROUEN | INSA-ROUEN | CNRS | COBRA | COMUE-NORMANDIE | INC-CNRS | INSA-GROUPE | ENSICAEN | UNILEHAVRE | UNICAEN

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Julien Godeau, Anthony Martinet, Vincent Levacher, Corinne Fruit, Thierry Besson. Efficient Microwave-Assisted Synthesis of Methyl 4- or 5-Nitro­anthranilate. SYNTHESIS, Georg Thieme Verlag, 2016, 48 (20), pp.3504-3508. ⟨10.1055/s-0035-1562484⟩. ⟨hal-02046207⟩

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