Efficient Microwave-Assisted Synthesis of Methyl 4- or 5-Nitro­anthranilate

Julien Godeau (1) , Anthony Martinet (2) , Vincent Levacher (1) , Corinne Fruit (1) , Thierry Besson (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 Anton Paar France

A novel method for the synthesis of anthranilate esters is described. The esterification reaction of nitro-substituted anthranilic acids was carried out under microwave irradiation. A range of solvents and other reaction parameters were investigated to provide the most environmentally friendly reaction conditions. The feasibility of scale-up was demonstrated, allowing a simple and inexpensive production of anthranilate esters.

Keywords: Hydrolysis; One-pot reactions; Microwave chemistry; Green solvent; Sustainable chemistry

Domains: Chemical Sciences

Julien Godeau, Anthony Martinet, Vincent Levacher, Corinne Fruit, Thierry Besson. Efficient Microwave-Assisted Synthesis of Methyl 4- or 5-Nitro­anthranilate. Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (20), pp.3504-3508. ⟨10.1055/s-0035-1562484⟩. ⟨hal-02046207⟩