1-Aza-2-alkyl-6-aryl-cycloalkanes usefull as memory enhancers

Sylvain Rault , Olivier Renault , Jean Guillon , Patrick Dallemagne (1) , Pierre Renard , Bruno Pfeiffer , Pierre Lestage , Marie-Cecile Lebrun

1 CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie

1-Aza-2-alkyl-6-aryl cycloalkanes (I) are new. 1-Aza-2-alkyl-6-aryl cycloalkanes of formula (I), their isomers and acid addition salts, are new. n = 0 or 1; R1 = H, aryl-1-6C alkyl, 1-6C alkyl or acyl, 1-6C alkoxycarbonylaryl-1-6C alkoxy carbonyl, or CF3; R2 = 1-6C alkyl; X = O, Cl, OR3, SR4, or NOR5; R3 = H, 1-6C alkyl or acyl, 1-6C alkoxycarbonyl, or aryl 1-6C alkoxycarbonyl; R4 = H, 1-6C alkyl, or aryl; R5 = H, 1-6C alkyl(optionally substituted by one or more groups selected from OH, amino that may be substituted by one or two alkyl groups, or 1-6C alkoxy; the dotted line = an optional bond; and Ar = aryl or heteroaryl; with the proviso that (I) is not any of the following: 6-methyl-2-phenyl-2,3-dihydro-4-pyridinone; 2-methyl-6-phenyl-4-piperidinone; N-benzyl-2-(R'2)-6-phenyl-4-piperidinones where R'2 is methyl, ethyl, propyl, or isopropyl; or 2-(R2)-6-phenyl-4-piperidinols where R2 is isopropyl or butyl.

Domaines: Chimie

Sylvain Rault, Olivier Renault, Jean Guillon, Patrick Dallemagne, Pierre Renard, et al.. 1-Aza-2-alkyl-6-aryl-cycloalkanes usefull as memory enhancers. France, Patent n° : EP1050530 (A1). 2000. ⟨hal-02042940⟩