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Palladium-catalyzed synthesis of 3-trifluoromethylated 1,3-dienes from acrylate derivatives and BTP

Abstract : Here we reported a Pd-catalyzed coupling reaction between acrylate derivatives and BTP (2-bromo-3,3,3-trifluoropropene) to access 3-trifluoromethylated 1,3-dienes. The reaction allows the formation of the corresponding products in good to excellent yields and moderate Z/E diastereoisomeric ratios. This method broadens the current toolbox to access 3-trifluoromethylated 1,3-dienes.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02024541
Contributor : Madeleine Roux-Merlin <>
Submitted on : Tuesday, February 19, 2019 - 11:11:18 AM
Last modification on : Thursday, July 2, 2020 - 3:30:02 AM

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Qun Zhao, Jianjun Wang, Tatiana Besset, Xavier Pannecoucke, J.-P. Bouillon, et al.. Palladium-catalyzed synthesis of 3-trifluoromethylated 1,3-dienes from acrylate derivatives and BTP. Tetrahedron, Elsevier, 2018, 74 (41), pp.6033-6040. ⟨10.1016/j.tet.2018.08.035⟩. ⟨hal-02024541⟩

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