Study of the Cross-Metathesis Reaction of α-Hydroxy β,γ-Unsaturated Amides towards a Rapid and Flexible Total ­Synthesis of Symbioramide and its Isomer

Alexandre Gratais (1) , Samir Bouzbouz (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

The reactivity of novel α-hydroxy β,γ-unsaturated amides in cross-metathesis reactions was extensively studied and used to perform a short total synthesis of symbioramide and its isomer from ­l-serine methyl ester.

Mots clés: Cross-metathesis; Symbioramide; Synthesis; Hydroxyamide; γ-silyl butenamides

Domaines: Chimie

Alexandre Gratais, Samir Bouzbouz. Study of the Cross-Metathesis Reaction of α-Hydroxy β,γ-Unsaturated Amides towards a Rapid and Flexible Total ­Synthesis of Symbioramide and its Isomer. SYNLETT, 2018, 29 (2), pp.230-234. ⟨10.1055/s-0036-1588579⟩. ⟨hal-02024500⟩