An electrophilic reagent for the synthesis of OCHFMe-containing molecules

Elodie Carbonnel (1) , Xavier Pannecoucke (1) , Tatiana Besset (1) , Philippe Jubault (1) , Thomas Poisson (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

Herein the synthesis of a novel and bench stable electrophilic reagent to construct the OCFHMe motif from O-nucleophiles has been described. This sulfonium salt, readily obtained in 5 steps, reacted with various phenols and alcohols. The resulting products, including complex molecules, were obtained in good yields. This reagent was also used for the functionalization of thiol derivatives.

Domains: Chemical Sciences

Elodie Carbonnel, Xavier Pannecoucke, Tatiana Besset, Philippe Jubault, Thomas Poisson. An electrophilic reagent for the synthesis of OCHFMe-containing molecules. Chemical Communications, 2018, 54 (20), pp.2491-2493. ⟨10.1039/c8cc00921j⟩. ⟨hal-02024482⟩