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One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis

Abstract : Tertiary alkyl fluorides have been prepared from methyl oxalates derived from tertiary alcohols by a sequential one-pot hydrolysis/photoredox catalyzed radical deoxyfluorination sequence. The reaction operates under mild conditions and tolerates a wide range of functional groups. This method provides an alternative approach to ionic deoxyfluorination transformations for the incorporation of Carbone–Fluorine quaternary centers into organic molecules.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02024481
Contributor : Madeleine Roux-Merlin <>
Submitted on : Tuesday, February 19, 2019 - 11:09:03 AM
Last modification on : Thursday, July 2, 2020 - 3:28:50 AM

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Julien Brioche. One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis. Tetrahedron Letters, Elsevier, 2018, 59 (50), pp.4387-4391. ⟨10.1016/j.tetlet.2018.10.063⟩. ⟨hal-02024481⟩

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