One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis - Normandie Université Accéder directement au contenu
Article Dans Une Revue Tetrahedron Letters Année : 2018

One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis

Résumé

Tertiary alkyl fluorides have been prepared from methyl oxalates derived from tertiary alcohols by a sequential one-pot hydrolysis/photoredox catalyzed radical deoxyfluorination sequence. The reaction operates under mild conditions and tolerates a wide range of functional groups. This method provides an alternative approach to ionic deoxyfluorination transformations for the incorporation of Carbone–Fluorine quaternary centers into organic molecules.

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Chimie
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Dates et versions

hal-02024481 , version 1 (19-02-2019)

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Citer

Julien Brioche. One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis. Tetrahedron Letters, 2018, 59 (50), pp.4387-4391. ⟨10.1016/j.tetlet.2018.10.063⟩. ⟨hal-02024481⟩
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