Synthesis of α-Fluorinated Acrylates by a Palladium-Catalyzed Decarboxylative Olefination Reaction

Ouafa Bouazzaoui , Kevin Rousée (1) , Joseph Kajima Mulengi , Xavier Pannecoucke (1) , J.-P. Bouillon (1) , Samuel Couve-Bonnaire (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

Ligand‐free palladium‐catalyzed subsequent decarboxylation/olefination reaction between 2‐fluorinated acrylates and benzoic acids is reported. Valuable trisubstituted 2‐fluoroacrylates and 2‐trifluoromethylacrylates were produced in low to excellent yields, which constitutes a new interesting greener synthetic alternative to these fluorinated molecules.

Domains: Chemical Sciences

Ouafa Bouazzaoui, Kevin Rousée, Joseph Kajima Mulengi, Xavier Pannecoucke, J.-P. Bouillon, et al.. Synthesis of α-Fluorinated Acrylates by a Palladium-Catalyzed Decarboxylative Olefination Reaction. European Journal of Organic Chemistry, 2018, Special Issue: Organofluorine Chemistry in Europe, 2018 (27-28), pp.3705-3715. ⟨10.1002/ejoc.201701709⟩. ⟨hal-02024480⟩