MRI probes based on C6-peracetate β-cyclodextrins: Synthesis, gadolinium complexation and in vivo relaxivity studies

Anais Biscotti (1) , Cécile Barbot (1) , Lionel Nicol (2) , Paul Mulder (2) , Célia Sappei (2) , Marie Hubert-Roux (2) , Isabelle Déchamps-Olivier (3) , François Estour (1) , Géraldine Gouhier (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 IRIB - Institute for Research and Innovation in Biomedicine
3 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312

The initial synthesis of two β-cyclodextrin derivatives bearing seven carboxylate ligands was optimized in order to improve the production of contrast agents. A speciation study using potentiometric analysis was performed on a gadolinium(III) complex. The in vivo myocardic activity was evaluated on mice. This study highlights the best efficiency for the cyclodextrin derivative having free hydroxyl groups and validated the biomedical potential of the flexible cyclodextrin scaffold as a cardiac MRI probe.

Mots clés: Organic synthesis; Association constant; MRI in vivo study; Cyclodextrin; Contrast agent

Domaines: Chimie

Anais Biscotti, Cécile Barbot, Lionel Nicol, Paul Mulder, Célia Sappei, et al.. MRI probes based on C6-peracetate β-cyclodextrins: Synthesis, gadolinium complexation and in vivo relaxivity studies. Polyhedron, 2018, 148, pp.32-43. ⟨10.1016/j.poly.2018.03.013⟩. ⟨hal-02024474⟩