 |
Journal articles
Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents
Abstract : Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here we describe the development of two families of pyridazinone derivatives as potential PDE4 inhibitors and their evaluation as anti-inflammatory agents. Among these derivatives, 4,5-dihydropyridazinone representatives possess promising activity, selectivity towards PDE4 isoenzymes and are able to reduce IL-8 production by human primary polymorphonuclear cells.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02024470
Contributor : Madeleine ROUX-MERLIN Connect in order to contact the contributor
Submitted on : Tuesday, February 19, 2019 - 11:08:37 AM
Last modification on : Tuesday, October 18, 2022 - 4:24:25 AM
Contributor : Madeleine ROUX-MERLIN Connect in order to contact the contributor
Submitted on : Tuesday, February 19, 2019 - 11:08:37 AM
Last modification on : Tuesday, October 18, 2022 - 4:24:25 AM
