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Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents

Abstract : Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here we describe the development of two families of pyridazinone derivatives as potential PDE4 inhibitors and their evaluation as anti-inflammatory agents. Among these derivatives, 4,5-dihydropyridazinone representatives possess promising activity, selectivity towards PDE4 isoenzymes and are able to reduce IL-8 production by human primary polymorphonuclear cells.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02024470
Contributor : Madeleine Roux-Merlin <>
Submitted on : Tuesday, February 19, 2019 - 11:08:37 AM
Last modification on : Thursday, September 10, 2020 - 3:45:01 PM

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Chantal Barberot, Aurélie Moniot, Ingrid Allart-Simon, Laurette Malleret, Tatyana Yegorova, et al.. Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents. European Journal of Medicinal Chemistry, Elsevier, 2018, 146, pp.139-146. ⟨10.1016/j.ejmech.2018.01.035⟩. ⟨hal-02024470⟩

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