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Journal Articles European Journal of Medicinal Chemistry Year : 2018

Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents

Abstract

Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here we describe the development of two families of pyridazinone derivatives as potential PDE4 inhibitors and their evaluation as anti-inflammatory agents. Among these derivatives, 4,5-dihydropyridazinone representatives possess promising activity, selectivity towards PDE4 isoenzymes and are able to reduce IL-8 production by human primary polymorphonuclear cells.
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Dates and versions

hal-02024470 , version 1 (19-02-2019)

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Chantal Barberot, Aurélie Moniot, Ingrid Allart-Simon, Laurette Malleret, Tatyana Yegorova, et al.. Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents. European Journal of Medicinal Chemistry, 2018, 146, pp.139-146. ⟨10.1016/j.ejmech.2018.01.035⟩. ⟨hal-02024470⟩
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