Skip to Main content Skip to Navigation
New interface
Journal articles

Modeling intratumor heterogeneity through CRISPR-barcodes

Abstract : We have devised a barcoding strategy to recapitulate cancer evolution through the emergence of subclonal mutations of interest, whose effects can be monitored in a dynamic manner. This approach can be easily adapted for a variety of applications, including combined modeling of multiple mechanisms of drug resistance or repair of oncogenic driver mutations in addicted cancer cells.
Document type :
Journal articles
Complete list of metadata

Cited literature [16 references]  Display  Hide  Download

https://hal-normandie-univ.archives-ouvertes.fr/hal-02017522
Contributor : Luca Grumolato Connect in order to contact the contributor
Submitted on : Tuesday, July 23, 2019 - 11:59:43 AM
Last modification on : Friday, March 11, 2022 - 2:09:47 PM

Links full text

Identifiers

Collections

Citation

Alexis Guernet, Stuart A. Aaronson, Youssef Anouar, Luca Grumolato. Modeling intratumor heterogeneity through CRISPR-barcodes. Molecular & Cellular Oncology, 2016, 3 (6), pp.e1227894. ⟨10.1080/23723556.2016.1227894⟩. ⟨hal-02017522⟩

Share

Metrics

Record views

39