Abstract : We have devised a barcoding strategy to recapitulate cancer evolution through the emergence of subclonal mutations of interest, whose effects can be monitored in a dynamic manner. This approach can be easily adapted for a variety of applications, including combined modeling of multiple mechanisms of drug resistance or repair of oncogenic driver mutations in addicted cancer cells.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02017522 Contributor : Luca GrumolatoConnect in order to contact the contributor Submitted on : Tuesday, July 23, 2019 - 11:59:43 AM Last modification on : Friday, March 11, 2022 - 2:09:47 PM