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Modeling intratumor heterogeneity through CRISPR-barcodes

Abstract : We have devised a barcoding strategy to recapitulate cancer evolution through the emergence of subclonal mutations of interest, whose effects can be monitored in a dynamic manner. This approach can be easily adapted for a variety of applications, including combined modeling of multiple mechanisms of drug resistance or repair of oncogenic driver mutations in addicted cancer cells.
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Contributor : Luca Grumolato Connect in order to contact the contributor
Submitted on : Tuesday, July 23, 2019 - 11:59:43 AM
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Alexis Guernet, Stuart A. Aaronson, Youssef Anouar, Luca Grumolato. Modeling intratumor heterogeneity through CRISPR-barcodes. Molecular & Cellular Oncology, 2016, 3 (6), pp.e1227894. ⟨10.1080/23723556.2016.1227894⟩. ⟨hal-02017522⟩



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