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Journal articles
Isolation and Structural Characterization of Two Novel Peptides Derived from Proopiomelanocortin in the Pituitary of the Rainbow Trout
Abstract : The trout possesses two POMC genes as a result of duplication of its genome some 25-100 million years ago. One of the POMC molecules exhibits a unique C-terminal extension of 25 amino acid residues which is not found in any other POMC characterized so far. In order to isolate possible novel peptides derived from trout POMC-A, we have raised antibodies against two synthetic epitopes derived from the C-terminal region of the precursor. Two native decapeptides were isolated in pure form from an extract of trout pituitary. The primary structures of these peptides were established as Glu-Gln-Trp-Gly-Arg-Glu-Glu-Gly-Glu-Glu and Ala-Leu-Gly-Glu-Arg-Lys-Tyr-His-Phe-Gln-NH2. The structure of the trout POMC-A cDNA reveals that both peptides are flanked by pairs of basic amino acids or a glycine residue, indicating that they can actually be generated during post-translational processing of POMC-A.
https://hal-normandie-univ.archives-ouvertes.fr/hal-01974282
Contributor : Jérôme Leprince <>
Submitted on : Tuesday, January 8, 2019 - 4:44:25 PM
Last modification on : Thursday, July 25, 2019 - 2:24:48 PM
Contributor : Jérôme Leprince <>
Submitted on : Tuesday, January 8, 2019 - 4:44:25 PM
Last modification on : Thursday, July 25, 2019 - 2:24:48 PM
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