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Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts

Abstract : Urotensin II (UII) was first discovered in the urophyses of goby fish and later identified in mammals, while urotensin II-related peptide (URP) was recently isolated from rat brain. We studied the effects of UII on isolated heart preparations of Chinook salmon and Sprague-Dawley rats. Native rat UII caused potent and sustained, dose-dependent dilation of the coronary arteries in the rat, whereas non-native UII (human and trout UII) showed attenuated vasodilation. Rat URP dilated rat coronary arteries, with 10-fold less potency compared with rUII. In salmon, native trout UII caused sustained dilation of the coronary arteries, while rat UII and URP caused significant constriction. Nomega-nitro-(l)-arginine methyl (l-NAME) and indomethacin significantly attenuated the URP and rat UII-induced vasodilation in the rat heart. We conclude that UII is a coronary vasodilator, an action that is species form specific. We also provide the first evidence for cardiac actions of URP, possibly via mechanisms common with UII.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01973974
Contributor : Jérôme Leprince <>
Submitted on : Tuesday, January 8, 2019 - 3:14:40 PM
Last modification on : Friday, April 24, 2020 - 2:44:04 PM

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H.C.G. Prosser, Jérôme Leprince, H. Vaudry, A.M. Richards, M.E. Forster, et al.. Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts. Peptides, Elsevier, 2006, 27 (12), pp.3261-3268. ⟨10.1016/j.peptides.2006.09.012⟩. ⟨hal-01973974⟩

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