Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts

Hamish Cg Prosser (1) , Jérôme Leprince (2, 3) , Hubert Vaudry (2, 3) , a Mark Richards (4) , Malcom E Forster (1) , Christopher J Pemberton (4)

1 University of Canterbury [Christchurch]
2 Neuroendocrinologie cellulaire et moléculaire
3 IFRMP 23 - Institut Fédératif de Recherches Multidisciplinaires sur les Peptides
4 University of Otago [Dunedin, Nouvelle-Zélande]

Urotensin II (UII) was first discovered in the urophyses of goby fish and later identified in mammals, while urotensin II-related peptide (URP) was recently isolated from rat brain. We studied the effects of UII on isolated heart preparations of Chinook salmon and Sprague-Dawley rats. Native rat UII caused potent and sustained, dose-dependent dilation of the coronary arteries in the rat, whereas non-native UII (human and trout UII) showed attenuated vasodilation. Rat URP dilated rat coronary arteries, with 10-fold less potency compared with rUII. In salmon, native trout UII caused sustained dilation of the coronary arteries, while rat UII and URP caused significant constriction. Nomega-nitro-(l)-arginine methyl (l-NAME) and indomethacin significantly attenuated the URP and rat UII-induced vasodilation in the rat heart. We conclude that UII is a coronary vasodilator, an action that is species form specific. We also provide the first evidence for cardiac actions of URP, possibly via mechanisms common with UII.

Domaines: Chimie thérapeutique; Interactions cellulaires [q-bio.CB]; Neurobiologie; Pharmacologie

Hamish Cg Prosser, Jérôme Leprince, Hubert Vaudry, a Mark Richards, Malcom E Forster, et al.. Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts. Peptides, 2006, 27 (12), pp.3261-3268. ⟨10.1016/j.peptides.2006.09.012⟩. ⟨hal-01973954⟩