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Interactions between oestrogen and 1α,25(OH)2-vitamin D3 signalling and their roles in spermatogenesis and spermatozoa functions

Abstract : Oestrogens and 1α,25(OH)2-vitamin D3 (1,25-D3) are steroids that can provide effects by binding to their receptors localised in the cytoplasm and in the nucleus or the plasma membrane respectively inducing genomic and non-genomic effects. As confirmed notably by invalidation of the genes, coding for their receptors as tested with mice with in vivo and in vitro treatments, oestrogens and 1,25-D3 are regulators of spermatogenesis. Moreover, some functions of ejaculated spermatozoa as viability, DNA integrity, motility, capacitation, acrosome reaction and fertilizing ability are targets for these hormones. The studies conducted on their mechanisms of action, even though not completely elicited, have allowed the demonstration of putative interactions between their signalling pathways that are worth examining more closely. The present review focuses on the elements regulated by oestrogens and 1,25-D3 in the testis and spermatozoa as well as the interactions between the signalling pathways of both hormones.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-01973789
Contributor : Hélène Bouraïma-Lelong <>
Submitted on : Tuesday, January 8, 2019 - 2:46:27 PM
Last modification on : Monday, May 4, 2020 - 5:00:04 PM

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Ana Paula Zanatta, Vanessa Brouard, Camille Gautier, Renata Goncalves, Hélène Bouraïma Lelong, et al.. Interactions between oestrogen and 1α,25(OH)2-vitamin D3 signalling and their roles in spermatogenesis and spermatozoa functions. Basic and clinical andrology, BioMed Central, 2017, 27 (1), ⟨10.1186/s12610-017-0053-z⟩. ⟨hal-01973789⟩

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