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Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies

Abstract : The neuropeptide 26RFa and its cognate receptor GPR103 are involved in the control of food intake and bone mineralization. Here, we have tested, experimentally, the predicted ligand-receptor interactions by site-directed mutagenesis of GPR103 and designed point-substituted 26RFa analogues.
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Submitted on : Tuesday, January 8, 2019 - 1:56:53 PM
Last modification on : Saturday, June 25, 2022 - 9:52:48 AM

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Cindy Neveu, Fabienne Dulin, Benjamin Lefranc, Ludovic Galas, Colas Calbrix, et al.. Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies. British Journal of Pharmacology, Wiley, 2014, 171 (19), pp.4425-4439. ⟨10.1111/bph.12808⟩. ⟨hal-01973604⟩

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