Role of PACAP and VIP in astroglial functions

Olfa Masmoudi-Kouki (1, 2, 3) , Pierrick Gandolfo (1, 2, 4) , Hélène Castel (1, 2, 4) , Jérôme Leprince (1, 2, 4) , Alain Fournier (5, 4) , Agnieszka Dejda (2, 1, 4, 6) , Hubert Vaudry (1, 2, 4) , Marie-Christine Tonon (1, 2, 4)

1 Neuroendocrinologie cellulaire et moléculaire
2 IFRMP 23 - Institut Fédératif de Recherches Multidisciplinaires sur les Peptides
3 FST - Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis
4 International Associated laboratory Samuel de Champlain
5 INRS-IAF - Institut Armand Frappier
6 PAN - Polish Academy of Sciences

Astrocytes represent at least 50% of the volume of the human brain. Besides their roles in various supportive functions, astrocytes are involved in the regulation of stem cell proliferation, synaptic plasticity and neuroprotection. Astrocytes also influence neuronal physiology by responding to neurotransmitters and neuropeptides and by releasing regulatory factors termed gliotransmitters. In particular, astrocytes express the PACAP-specific receptor PAC1-R and the PACAP/VIP mutual receptors VPAC1-R and VPAC2-R during development and/or in the adult. There is now clear evidence that PACAP and VIP modulate a number of astrocyte activities such as proliferation, plasticity, glycogen production, and biosynthesis of neurotrophic factors and gliotransmitters.

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology; Life Sciences [q-bio]; Pharmaceutical sciences; Pharmacology

Olfa Masmoudi-Kouki, Pierrick Gandolfo, Hélène Castel, Jérôme Leprince, Alain Fournier, et al.. Role of PACAP and VIP in astroglial functions. Peptides, 2007, 28 (9), pp.1753-1760. ⟨10.1016/j.peptides.2007.05.015⟩. ⟨hal-01973029⟩